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Hematology – Physiology – Part 3 – Video

Hematology – Physiology – Part 3
Lecture series by G. Fuller, who has been teaching Physiology course for 35 years. This was the last semester teaching before he retired. In this lecture, yo…

By: Wizard of Science

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Hematology – Physiology – Part 3 – Video

Spectrum Pharmaceuticals Pivotal Trial of Captisol-Enabled (Propylene Glycol-Free) Melphalan Meets Primary Endpoint

Spectrum Pharmaceuticals , a biotechnology company with fully integrated commercial and drug development operations with a primary focus in Hematology and Oncology,

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Spectrum Pharmaceuticals Pivotal Trial of Captisol-Enabled (Propylene Glycol-Free) Melphalan Meets Primary Endpoint

Probe finished in controversial stemcell therapy

Next step by prosecutors could be indictments

(ANSA) – Turin, April 23 – Prosecutors said Wednesday they have completed their investigation into a controversial stem-cell treatment involving 20 individuals, including Davide Vannoni, founder of the Stamina Foundation. The notice means prosecutors could now proceed to indictments in the case that may involve charges of fraud. Earlier this month, hospitals in Italy that used the discredited stem-cell treatment announced they have suspended the program. That followed announcements last fall by Italy’s health that the Stamina Foundation – the nonprofit foundation that developed the treatment – would not be allowed to test it on humans. The foundation was also stripped of its non-profit status after a study found its treatment was “ignorant of stem-cell biology”. Vannoni, a former psychology lecturer, was indicted earlier this year for alleged attempted fraud against the Piedmont Region. The Stamina Foundation had asked for 500,000 euros of funding to develop a stem-cell laboratory, a request prosecutors had earlier argued was fraudulent because the efficacy of the treatment has been “completely disproved”. The Stamina treatment involves extracting bone-marrow stem cells from a patient, turning them into neurons by exposing them to retinoic acid for two hours, and injecting them back into the patient. Supporters of the therapy thought it could be a cure for fatal degenerative nerve diseases such as spinal muscular atrophy, while detractors said it was devoid of scientific merit. A panel of experts appointed by Italy’s health ministry said in January it found the therapy seriously lacking in both premise and practice. Their report cited “serious imperfections and omissions in the Stamina protocol, including conceptual errors and an apparent ignorance of stem-cell biology”.

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Probe finished in controversial stemcell therapy

Outstanding psoriasis treatment with DermaPro Beauty Cream – Video

Outstanding psoriasis treatment with DermaPro Beauty Cream
DermaPro has the highest concentration of Seabuckthorn Oil on the market!!! The active ingredient, Seabuckthorn Oil, is clinically proven to kill the Human D…

By: Linda James

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Outstanding psoriasis treatment with DermaPro Beauty Cream – Video

Coloured Paranoa – Psoriasis "Chemical Notes" – Video

Coloured Paranoa – Psoriasis “Chemical Notes”
Third Track of “Chemical Notes” – Psoriasis Credit: I've remixed a track named november on is website:

By: Coloured Paranoa

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Coloured Paranoa – Psoriasis "Chemical Notes" – Video

Psoriatic arthritis affects many people

People who suffer from psoriasis or have a family history of this skin condition may be at risk for psoriatic arthritis, a serious disease that causes extensive swelling and joint pain.

The Psoriasis and Psoriatic Arthritis Education Center notes that up to 30 percent of people with psoriasis also develop psoriatic arthritis. Psoriasis is an auto-immune skin condition in which the skin reproduces cells at an accelerated rate. This causes patches of flaky, irritated skin, also known as plaques. Psoriatic arthritis can develop at any time, but it is common between the ages of 30 and 50. Environmental factors, genes and immune system responses play a role in the onset of the disease. Patients with psoriatic arthritis can develop inflammation of their tendons, cartilage, eyes, lung lining, and sometimes aorta.

Psoriasis and psoriatic arthritis do not necessarily occur at the same time. Psoriasis generally comes first and then is followed by the joint disease. The skin ailment precedes the arthritis in nearly 80 percent of patients. Psoriatic arthritis is a rheumatic disease that can affect body tissues as well as joints. Psoriatic arthritis shares many features with several other arthritic conditions, such as ankylosing spondylitis, reactive arthritis and arthritis associated with Crohns disease and ulcerative colitis.

The rate of onset of psoriatic arthritis varies among people. For some it can develop slowly with mild symptoms. Others find it comes on quickly and is severe. Symptoms of the disease also vary, but may include the following;

* generalized fatigue

* swollen fingers and toes

* stiffness, pain, throbbing, swelling, and tenderness in joints

* reduced range of motion

* changes in fingernails

* redness and pain of the eyes

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Psoriatic arthritis affects many people

Scientists seek genetic clues to longevity from 115-year-old woman

More than 400 mutations were found in the healthy white blood cells of a 115-year-old woman, according to a new study that may advance what is known about limits of the human life span.

Genetic mutations have been linked to diseases such as cancer, but these findings suggest that mutations in white blood cells are largely harmless over a lifetime, the researchers said.

Blood is continually replenished by hematopoietic (meaning “to make blood”) stem cells that are inside the bone marrow and divide to produce different types of blood cells.

Cell division can lead to genetic mutations and hundreds of mutations have been found in patients with blood cancers. However, little was known about white blood cells and mutations.

The woman in the study – whose name was not revealed – was the oldest person in the world when she died in 2005. She is thought to be the oldest person ever to donate her body to science. The hundreds of mutations identified in her white blood cells appeared to be tolerated by the body and did not cause disease.

The researchers also found possible new insight into the limits of human longevity, according to the authors of the study published online April 23 in the journal Genome Research.

“To our great surprise we found that, at the time of her death, the peripheral blood was derived from only two active hematopoietic stem cells (in contrast to an estimated 1,300 simultaneously active stem cells), which were related to each other,” lead author Dr. Henne Holstege said in a journal news release.

The researchers also found that the woman’s white blood cells’ telomeres were extremely short. Telomeres, which are at the ends of chromosomes and protect them from damage, get a bit shorter each time a cell divides.

“Because these blood cells had extremely short telomeres, we speculate that most hematopoietic stem cells may have died from ‘stem cell exhaustion,’ reaching the upper limit of stem cell divisions,” Holstege said.

Further research is needed to learn whether such stem cell exhaustion is a cause of death in extremely old people.

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Scientists seek genetic clues to longevity from 115-year-old woman

Wake Forest Institute for Regenerative Medicine – Official Site

An International Leader in Regenerative Medicine

The Wake Forest Institute for Regenerative Medicine (WFIRM) is a leader in translating scientific discovery into clinical therapies.

Physicians and scientists at WFIRM were the first in the world to engineer laboratory-grown organs that were successfully implanted into humans. Today, this interdisciplinary team is working to engineer more than 30 different replacement tissues and organs and to develop healing cell therapies-all with the goal to cure, rather than merely treat, disease.

Regenerative medicine has been called the “next evolution of medical treatments,” by the U.S. Department of Health and Human Services. With its potential to heal, this new field of science is expected to revolutionize health care.

“We have many challenges to meet, but are optimistic about the ability of the field to have a significant impact on human health. We believe regenerative medicine promises to be one of the most pervasive influences on public health in the modern era.”- Anthony Atala, MD, Director

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Wake Forest Institute for Regenerative Medicine – Official Site